List of matches in this round
- TimeMatch
- August 29, 2022
- 6:00 pmSuwannee Bulldogs48 - 0Seminoles
- September 1, 2022
- 6:00 pmWest Gasden Panthers0 - 46Seminoles
- September 13, 2022
- 6:00 pmMadison County Cowboys16 - 28Seminoles
- September 22, 2022
- 6:00 pmWakulla Eagles24 - 20Seminoles
- September 29, 2022
- 7:00 pmSeminoles14 - 18Marianna Bullpups
- October 13, 2022
- 6:00 pmTaylor County Bulldogs20 - 22Seminoles